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京都大学大学院医学研究科医学専攻分子生体統御学講座医化学分野。竹内研究室です。

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研究業績publication

2024年

  1. Yoshinaga, M., Takeuchi, O. (2024). Regulation of inflammatory diseases via the control of mRNA decay. Inflamm. Regen. 44, 14. doi: 10.1186/s41232-024-00326-5. [PubMed], [Inflamm. Regen.].
  2. Yoshinaga, M., Takeuchi, O. (2024). RNA Metabolism Governs Immune Function and Response. Adv. Exp. Med. Biol. 1444, 145-161. doi: 10.1007/978-981-99-9781-7_10. [PubMed], [Adv. Exp. Med. Biol.].
  3. Uehata, T., Yamada, S., Ori, D., Vandenbon, A., Giladi, A., Jelinski, A., Murakawa, Y., Watanabe, H., Takeuchi, K., Toratani, K., Mino, T., Kiryu, H., Standley, D.M., Tsujimura, T., Ikawa, T., Kondoh, G., Landthaler, M., Kawamoto, H., Rodewald, H.-R., Amit, I., Yamamoto, R., Miyazaki, M., Takeuchi, O. (2024). Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz. Blood 143, 243-257. doi: 10.1182/blood.2023020903. [PubMed], [Blood], [京大プレスリリース].

2023年

  1. Nakatsuka, Y., Murase, K., Sonomura, K., Tabara, Y., Nagasaki, T., Hamada, S., Matsumoto, T., Minami, T., Kanai, O., Takeyama, H., Sunadome, H., Takahashi, N., Nakamoto, I., Tanizawa, K., Handa, T., Sato, T., Komenami, N., Wakamura, T., Morita, S., Takeuchi, O., Nakayama, T., Hirai, T., Kamatani, Y., Matsuda F., Chin, K. (2023). Hyperfructosemia in sleep disordered breathing: metabolome analysis of Nagahama study. Scientific Reports 13, 12735. doi: 10.1038/s41598-023-40002-1. [PubMed], [Scientific Reports].
  2. Yang, G., Lee, H.E., Trzeciak, M., Pawelczyk, T., Takeuchi, O., Kang, H.C., Cho, Y.-Y., Lee, H.S., Lee, J.Y. (2023). Regnase-1 plays an essential role in maintaining skin immune homeostasis via regulation of chemokine expression. Biomedicine & Pharmacotherapy 162, 114558. doi: 10.1016/j.biopha.2023.114558. [PubMed], [Biomedicine & Pharmacotherapy].

2022年

  1. Tse, K.M., Takeuchi, O. (2023). Innate immune sensing of pathogens and its post-transcriptional regulations by RNA-binding proteins. Archives of Pharmacal Research 46, 65-77. doi: 10.1007/s12272-023-01429-2. [PubMed], [Arch. Pharm. Res.], [Full text].
  2. Yoshinaga, M., Han, K., Morgens, D.W., Horii, T., Kobayashi, R., Tsuruyama, T., Hia, F., Yasukura, S., Kajiya, A., Cai, T., Cruz, P.H.C., Vandenbon, A., Suzuki, Y., Kawahara, Y., Hatada, I., Bassik, M.C., Takeuchi, O. (2022). The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity. Nature Communications 13, 6435. doi: 10.1038/s41467-022-34078-y. [PubMed], [Nat. Commun.], [京大プレスリリース].
  3. Ejima, A., Abe, S., Shimba, A., Sato, S., Uehata, T., Tani-ichi, S., Munakata, S., Cui, G., Takeuchi, O., Hirai, T., Kato, S., Ikuta, K. (2022). Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells. The Journal of Immunology 209, 1083-1094. doi: 10.4049/jimmunol.2200294. [PubMed], [J. Immunol.].
  4. Yaku, A., Inagaki, T., Asano, R., Okazawa, M., Mori, H., Sato, A., Hia, F., Masaki, T., Manabe, Y., Ishibashi, T., Vandenbon, A., Nakatsuka, Y., Akaki, K., Yoshinaga, M., Uehata, T., Mino, T., Morita, S., Ishibashi-Ueda, H., Morinobu, A., Tsujimura, T., Ogo, T., Nakaoka, Y., Takeuchi, O. (2022). Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages. Circulation 146, 1006–1022. doi: 10.1161/CIRCULATIONAHA.122.059435. [PubMed], [Circulation], [京大プレスリリース], [Editorial on Circulation], [EurekAlert], [RESEARCH NEWS on Kyoto University HP].
  5. Akaki, K., Mino, T., Takeuchi, O. (2022). DSP-crosslinking and Immunoprecipitation to Isolate Weak Protein Complex. Bio-protocol 12, e4478. doi: 10.21769/BioProtoc.4478. [Bio-protocol].
  6. Tse, K.M., Vandenbon, A., Cui, X., Mino, T., Uehata, T., Yasuda, K., Sato, A., Tsujimura, T., Hia, F., Yoshinaga, M., Kinoshita, M., Okuno, T., Takeuchi, O. (2022). Enhancement of Regnase-1 expression with stem loop–targeting antisense oligonucleotides alleviates inflammatory diseases. Science Translational Medicine 14, eabo2137. doi: 10.1126/scitranslmed.abo2137. [PubMed], [Sci. Transl. Med.], [AMEDプレスリリース], [京大プレスリリース], [日経バイオテク].
  7. Chong, Y.K., Tartey, S., Yoshikawa, Y., Imami, K., Li, S., Yoshinaga, M., Hirabayashi, A., Liu, G., Vandenbon, A., Hia, F., Uehata, T., Mino, T., Suzuk,i Y., Noda, T., Ferrandon, D., Standley, D.M., Ishihama, Y., Takeuchi, O. (2022). Cyclin J–CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism. Science Signaling 15, eabm5011. doi: 10.1126/scisignal.abm5011. [PubMed], [Science Signaling], [論文のfree full text リンクはこちら], [京大プレスリリース].

2021年

  1. Hikichi, Y., Motomura, Y., Takeuchi, O., Moro, K. (2021). Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin. Journal of Experimental Medicine 218, e20210181. doi: 10.1084/jem.20210181. [PubMed], [J. Exp. Med.].
  2. Wakabayashi, A., Yoshinaga, M., Takeuchi, O. (2021). TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation. Life Science Alliance 5, e202101067. doi: 10.26508/lsa.202101067. [PubMed], [Life Science Alliance].
  3. Akaki, K., Ogata, K., Yamauchi, Y., Iwai, N., Tse, K.M., Hia, F., Mochizuki, A., Ishihama, Y., Mino, T., Takeuchi, O. (2021). IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay. eLife 10, e71966. doi: 10.7554/eLife.71966. [PubMed], [eLife], [京大プレスリリース].
  4. Mino, T., Takeuchi, O. (2021). Regnase-1–related endoribonucleases in health and immunological diseases. Immunological Reviews 304, 97–110. doi: 10.1111/imr.13023. [PubMed], [Immunological Reviews].
  5. Uehata, T., Takeuchi, O. (2021). Post-transcriptional regulation of immunological responses by Regnase-1-related RNases. International Immunology 33, 859-865. doi: 10.1093/intimm/dxab048. [PubMed], [International Immunology].
  6. Tomita, T., Kato, M., Mishima, T., Matsunaga, Y., Sanjo, H., Ito, K., Minagawa, K., Matsui, T., Oikawa, H., Takahashi, S., Takao, T., Iwai, N., Mino, T., Takeuchi, O., Maru, Y., Hiratsuka, S. (2021). Extracellular mRNA transported to the nucleus exerts translation-independent function. Nature Communications 12(1), 3655. doi: 10.1038/s41467-021-23969-1. [PubMed], [Nat Commun.].
  7. Garg, A., Roske, Y., Yamada, S., Uehata, T., Takeuchi, O., Heinemann, U. (2021). PIN and CCCH Zn-finger domains coordinate RNA targeting in ZC3H12 family endoribonucleases. Nucleic Acids Research 49(9), 5369–5381. doi: 10.1093/nar/gkab316. [PubMed], [Nucleic Acids Research].
  8. Nakatsuka, Y., Yaku, A., Handa, T., Vandenbon, A., Hikichi, Y., Motomura, Y., Sato, A., Yoshinaga, M., Tanizawa, K., Watanabe, K., Hirai, T., Chin, K., Suzuki, Y., Uehata, T., Mino, T., Tsujimura, T., Moro, K., Takeuchi, O. (2021). Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-1. European Respiratory Journal 57, 2000018. doi: 10.1183/13993003.00018-2020. [PubMed], [Eur. Respir. J.][京大プレスリリース].
  9. Hia, F., Takeuchi, O. (2021). The effects of codon bias and optimality on mRNA and protein regulation. Cellular and Molecular Life Sciences 78, 1909–1928. doi: 10.1007/s00018-020-03685-7. [PubMed], [Cell. Mol. Life Sci.].

2020年

  1. Uehata, T., Takeuchi, O. (2020). RNA Recognition and Immunity-Innate Immune Sensing and Its Posttranscriptional Regulation Mechanisms. Cells 9, 1701. doi:10.3390/cells9071701. [PubMed], [MDPI].
  2. Miyazaki, K., Watanabe, H., Yoshikawa, G., Chen, K., Hidaka, R., Aitani, Y., Osawa, K., Takeda, R., Ochi, Y., Tani-Ichi, S., Uehata, T., Takeuchi, O., Ikuta, K., Ogawa, S., Kondoh, G., Lin, Y.C., Ogata, H., Miyazaki, M. (2020). The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells. Science Immunology 5, eabb1455. doi: 10.1126/sciimmunol.abb1455. [PubMed], [Science Immunology], [京大プレスリリース].
  3. Maruyama, K., Kidoya, H., Takemura, N., Sugisawa, E., Takeuchi, O., Kondo, T., Eid, M.M.A., Tanaka, H., Martino, M.M., Takakura, N., Takayama, Y., Akira, S., Vandenbon, A., Kumagai, Y. (2020). Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages. Cell Reports 32, 107906. doi: 10.1016/j.celrep.2020.107906. [PubMed], [Cell Reports].
  4. Gao, J., Hori, Y., Takeuchi, O., Kikuchi, K. (2020). Live-Cell Imaging of Protein Degradation Utilizing Designed Protein-Tag Mutant and Fluorescent Probe with Turn-Off Switch. Bioconjugate Chem. 31, 577-583. doi: 10.1021/acs.bioconjchem.9b00696. [PubMed], [ACS Publications].

2019年

  1. Kakiuchi, N., Yoshida, K., Uchino, M., Kihara, T., Akaki, K., Inoue, Y., Kawada, K., Nagayama, S., Yokoyama, A., Yamamoto, S., Matsuura, M., Horimatsu, T., Hirano, T., Goto, N., Takeuchi, Y., Ochi, Y., Shiozawa, Y., Kogure, Y., Watatani, Y., Fujii, Y., Kim, S.K., Kon, A., Kataoka, K., Yoshizato, T., Nakagawa, M.M., Yoda, A., Nanya, Y., Makishima, H., Shiraishi, Y., Chiba, K., Tanaka, H., Sanada, M., Sugihara, E., Sato, T., Maruyama, T., Miyoshi, H., Taketo, M.M., Oishi, J., Inagaki, R., Ueda, Y., Okamoto, S., Okajima, H., Sakai, Y., Sakurai, T., Haga, H., Hirota, S., Ikeuchi, H., Nakase, H., Marusawa, H., Chiba, T., Takeuchi, O., Miyano, S., Seno, H., Ogawa, S. (2019). Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis. Nature 577, 260-265. doi: 10.1038/s41586-019-1856-1. [Nature], [PubMed], [京大プレスリリース].
  2. Hia, F., Yang, S.F., Shichino, Y., Yoshinaga, M., Murakawa, Y., Vandenbon, A., Fukao, A., Fujiwara, T., Landthaler, M., Natsume, T., Adachi, S., Iwasaki, S., Takeuchi, O. (2019). Codon bias confers stability to human mRNAs. EMBO Reports 20, e48220. doi: 10.15252/embr.201948220. [EMBO Reports], [PubMed], [京大プレスリリース].
  3. Hirabayashi, S., Bhagat, S., Matsuki, Y., Takegami, Y., Uehata, T., Kanemaru, A., Itoh, M., Shirakawa, K., Takaori-Kondo, A., Takeuchi, O., Carninci, P., Katayama, S., Hayashizaki, Y., Kere, J., Kawaji H., Murakawa, Y. (2019). NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements. Nature Genetics 51, 1369–1379. doi: 10.1038/s41588-019-0485-9. [Nature Genetics], [PubMed], [理研プレスリリース]，[京大プレスリリース].
  4. Yoshinaga, M., Takeuchi, O. (2019). RNA binding proteins in the control of autoimmune diseases. Immunol. Med. 42, 53-64. doi: 10.1080/25785826.2019.1655192. [Immunol. Med.], [PubMed].
  5. Mino, T., Iwai, N., Endo, M., Inoue, K., Akaki, K., Hia, F., Uehata, T., Emura, T., Hidaka, K., Suzuki, Y., Standley, D.M., Okada-Hatakeyama, M., Ohno, S., Sugiyama, H., Yamashita, A., Takeuchi, O. (2019). Translation-dependent unwinding of stem–loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs. Nucleic Acids Research 47, 8838–8859. doi: 10.1093/nar/gkz628. [Nucleic Acids Research], [PubMed], [京大プレスリリース].
  6. Yoshinaga, M., Takeuchi, O. (2019). Post-transcriptional control of immune responses and its potential application. Clin. Transl. Immunology 8, e1063. doi: 10.1002/cti2.1063. [PMC full text], [PubMed].
  7. Yamasoba, D., Sato, K., Ichinose, T., Imamura, T., Koepke, L., Joas, S., Reith, E., Hotter, D., Misawa, N., Akaki, K., Uehata, T., Mino, T., Miyamoto, S., Noda, T., Yamashita, A., Standley, D.M., Kirchhoff, F., Sauter, D., Koyanagi, Y., Takeuchi, O. (2019). N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation. Nature Microbiology 4, 1532–1544. doi: 10.1038/s41564-019-0460-3. [Nature Microbiology], [Springer Nature (view only version)], [PubMed], [AMEDプレスリリース], [京大プレスリリース]，[京大ウイルス・再生医科学研究所HP].

2018年

  1. Wang, J., Sekai, M., Matsui, T., Fujii, Y., Matsumoto, M., Takeuchi, O., Minato, N., Hamazaki, Y. (2018). Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus. Int. Immunol. 31, 127–139. doi: 10.1093/intimm/dxy073. [PubMed], [International Immunology].
  2. Sadahiro, A., Fukao, A., Kosaka, M., Takizawa, N., Funakami, Y., Takeuchi, O., Duncan, K.E., Fujiwara, T. (2018). Translation of Hepatitis A virus IRES is upregulated by a hepatic cell-specific factor. Frontiers in Genetics 9, 307. doi: 10.3389/fgene.2018.00307. [Frontiers in Genetics], [PubMed]
  3. Nakatsuka, Y., Vandenbon, A., Mino, T., Yoshinaga, M., Uehata, T., Cui, X., Sato, A., Tsujimura, T., Suzuki, Y., Sato, A., Handa, T., Chin, K., Sawa, T., Hirai, T., Takeuchi, O. (2018). Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia. Mucosal Immunology 11, 1203-1218. doi: 10.1038/s41385-018-0024-5. [Mucosal Immunology], [Springer Nature (View only version)], [PubMed], [京大ウイルス再生研HP].
  4. Mino, T., Takeuchi, O. (2018). Post-transcriptional regulation of immune responses by RNA binding proteins. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 94, 248-258. doi: 10.2183/pjab.94.017. [Proceedings of the Japan Academy, Series B], [PubMed].
  5. Takeuchi, O. (2018). Endonuclease Regnase-1/Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) in controlling immune responses and beyond. Wiley Interdiscip Rev. RNA. 9, e1449. doi: 10.1002/wrna.1449. [Wiley Interdiscip Rev. RNA] [PubMed].

2017年

  1. Cui, X., Mino, T., Yoshinaga, M., Nakatsuka, Y., Hia, F., Yamasoba, D., Tsujimura, T., Tomonaga, K., Suzuki, Y., Uehata, T., Takeuchi, O. (2017). Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis. J. Immunol. 199, 4066-4077. doi: 10.4049/jimmunol.1701211. [The Journal of Immunology], [PubMed], [京大ウイルス再生研HP]
  2. Kozaki, T., Komano, J., Kanbayashi, D., Takahama, M., Misawa, T., Satoh, T., Takeuchi, O., Kawai, T., Shimizu, S., Matsuura, Y., Akira, S., Saitoh, T. (2017). Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. Proc. Natl. Acad. Sci. USA 114, 2681-2686. doi: 10.1073/pnas.1621508114.
  3. Yoshinaga, M., Nakatsuka, Y., Vandenbon, A., Ori, D., Uehata, T., Tsujimura, T., Suzuki, Y., Mino, T., Takeuchi, O. (2017). Regnase-1 maintains iron homeostasis via the degradation of transferrin receptor 1 and prolyl hydroxylase domain-containing protein 3 mRNAs. Cell Reports 19, 1614-1630. doi: 10.1016/j.celrep.2017.05.009. [Cell Press], [PubMed], [京大HP], [AMED-CREST], [ 京大ウイルス再生研HP]
  4. Mino, T., Takeuchi, O. (2017). NSD3 keeps IRF3 active. J. Exp. Med. 214, 3475-3476. doi: 10.1084/jem.20171980. [The Journal of Experimental Medicine] [PubMed].
  5. Uehata, T., Takeuchi, O. (2017). Regnase-1 Is an Endoribonuclease Essential for the Maintenance of Immune Homeostasis. J. Interferon Cytokine Res. 37, 220-229. doi: 10.1089/jir.2017.0001. [J. Interferon Cytokine Res.] [PubMed].
  6. Yamashita, A., Takeuchi, O. (2017). Translational control of mRNAs by 3'-untranslated region binding proteins. BMB Reports 50, 194-200. [BMB Reports] [PubMed]
  7. Tartey, S., Takeuchi, O. (2017). Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells. Int. Rev. Immunol. 36, 57-73. [Int. Rev. Immunol.] [PubMed].

2016年

  1. Ishikita, A., Matoba, T., Ikeda, G., Koga, J., Mao, Y., Nakano, K., Takeuchi, O., Sadoshima, J., Egashira, K. (2016). Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction. J. Am. Heart Assoc. 5, e003872.
  2. Masuda, K., Ripley, B., Nyati, K.K., Dubey, P.K., Zaman, M.M., Hanieh, H., Higa, M., Yamashita, K., Standley, D.M., Mashima, T., Katahira, M., Okamoto, T., Matsuura, Y., Takeuchi, O., Kishimoto, T. (2016). Arid5a regulates naive CD4+ T cell fate through selective stabilization of Stat3 mRNA. J. Exp. Med. 213, 605-619.
  3. Martino, M.M., Maruyama, K., Kuhn, G.A., Satoh, T., Takeuchi, O., Müller, R., Akira, S. (2016). Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration. Nat. Commun. 7, 11051.
  4. Yokogawa, M., Tsushima, T., Noda, N.N., Kumeta, H., Enokizono, Y., Yamashita, K., Standley, D.M., Takeuchi, O., Akira, S., Inagaki, F. (2016). Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions. Scientific Reports 6, 22324.

2015年

  1. Tartey, S., Matsushita, K., Imamura, T., Wakabayashi, A., Ori, D., Mino, T., Takeuchi, O. (2015). Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses. J. Immunol. 195, 519-527. doi: 10.4049/jimmunol.1500373. [The Journal of Immunology] [PubMed] [IVR Japanese, English].
  2. Mino, T., Murakawa, Y., Fukao, A., Vandenbon, A., Wessels, H.-H., Ori, D., Uehata, T., Tartey, S., Akira, S., Suzuki, Y., Vinuesa, C.G., Ohler, U., Standley,D.M., Landthaler, M., Fujiwara, T., Takeuchi, O. (2015). Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms. Cell 161, 1058–1073. doi: 10.1016/j.cell.2015.04.029. [Cell Press] [First Author Reflections] [PubMed] [Kyoto University] [JST] [IVR Japanese, English] [ライフサイエンス 新着論文レビュー] [科学新聞] [F1000Prime Exceptional].
  3. Fukasaka, M., Asari, D., Kiyotoh, E., Okazaki, A., Gomi, Y., Tanimoto, T., Takeuchi, O., Akira, S., Hori, M. (2015). A Lipopolysaccharide from Pantoea Agglomerans Is a Promising Adjuvant for Sublingual Vaccines to Induce Systemic and Mucosal Immune Responses in Mice via TLR4 Pathway. PLoS One 10, e0126849.
  4. Maruyama, K., Fukasaka, M., Uematsu, S., Takeuchi, O., Kondo, T., Saitoh, T., Martino, M., Akira, S. (2015). 5-azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival. J. Biol. Chem. 290, 9377-9386.
  5. Asakawa, S., Kishimoto, Y., Takano, T., Okita, K., Takakuwa, S., Sato, T., Hiratsuka, M., Takeuchi, O., Hirasawa, N. (2015). Nickel ions selectively inhibit lipopolysaccharide-induced interleukin-6 production by decreasing its mRNA stability. PLoS One 10, e0119428.
  6. Patel, M.N., Bernard, W.G., Milev, N.B., Cawthorn, W.P., Figg, N., Hart, D., Prieur, X., Virtue, S., Hegyi, K., Bonnafous, S., Bailly-Maitre, B., Chu, Y., Griffin, J.L., Mallat, Z., Considine, R.V., Tran, A., Gual, P., Takeuchi, O., Akira, S., Vidal-Puig, A., Bennett, M.R., Sethi, J.K. (2015). Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation. Proc. Natl. Acad. Sci. USA 112, 506-511.
  7. Kitai, Y., Takeuchi, O., Kawasaki, T., Ori, D., Sueyoshi, T., Murase, M., Akira, S., Kawai, T. (2015). Negative Regulation of Melanoma Differentiation-associated Gene 5 (MDA5)-dependent Antiviral Innate Immune Responses by Arf-like Protein 5B. J. Biol. Chem. 290, 1269-1280.
  8. Mino, T., Takeuchi, O. (2015). Regnase-1 and Roquin regulate inflammatory mRNAs. Oncotarget 6, 17869-17870. [Oncotarget] [PubMed].
  9. Takeuchi, O. (2015). HuR keeps Interferon-β mRNA stable. Eur. J. Immunol. 45, 1296-1299. [Eur. J. Immunol.] [PubMed].

2014年

  1. Vandenbon, A., Teraguchi, S., Takeuchi, O., Suzuki, Y., Standley, D.M. (2014). Dynamics of enhancers in myeloid antigen presenting cells upon LPS stimulation. BMC Genomics 15, S4.
  2. Bonnay, F., Nguyen, X.H., Cohen-Berros, E., Troxler, L., Batsche, E., Camonis, J., Takeuchi, O., Reichhart, J.M., Matt, N. (2014). Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling. EMBO J. 33, 2349-2362.
  3. Tartey, S., Matsushita, K., Vandenbon, A., Ori, D., Imamura, T., Mino, T., Standley, D.M., Hoffmann, J.A., Reichhart, J.M., Akira, S., Takeuchi, O. (2014). Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex. EMBO J. 33, 2332-2348. [EMBO J] [PubMed] [IVR Japanese, English]
  4. Imanishi, T., Ishihara, C., Badr Mel, S., Hashimoto-Tane, A., Kimura, Y., Kawai, T., Takeuchi, O., Ishii, K.J., Taniguchi, S., Noda, T., Hirano, H., Brombacher, F, Barber, G.N., Akira, S., Saito, T. (2014). Nucleic acid sensing by T cells initiates Th2 cell differentiation. Nat. Commun. 5, 3566.
  5. Kuniyoshi, K., Takeuchi, O., Pandey, S., Satoh, T., Iwasaki, H., Akira, S., Kawai, T. (2014). Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity. Proc. Natl. Acad. Sci. USA 111, 5646-5651.
  6. Mino, T., Mori, T., Aoyama, Y., Sera, T. (2014). Inhibition of DNA replication of human papillomavirus by using zinc finger-single-chain FokI dimer hybrid. Mol. Biotechnol. 56, 731-737.

2013年

  1. Ma, J., Bang, B.R., Lu, J., Eun, S.Y., Otsuka, M., Croft, M., Tobias, P., Han, J., Takeuchi, O., Akira, S., Karin, M., Yagita, H., Kang, Y.J. (2013). The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation. Sci. Signal. 6, ra87.
  2. Maruyama, K., Uematsu, S., Kondo, T., Takeuchi, O., Martino, M.M., Kawasaki, T., Akira, S. (2013). Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J. Exp. Med. 210, 1947-1960.
  3. Lee, H., Komano, J., Saitoh, Y., Yamaoka, S., Kozaki, T., Misawa, T., Takahama, M., Satoh, T., Takeuchi, O., Yamamoto, N., Matsuura, Y., Saitoh, T., Akira, S. (2013). Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus. Proc. Natl. Acad. Sci. USA 110, 12379-12384.
  4. Kawashima, T., Kosaka, A., Yan, H., Guo, Z., Uchiyama, R., Fukui, R., Kaneko, D., Kumagai, Y., You, D.J., Carreras, J., Uematsu, S., Jang, M.H., Takeuchi, O., Kaisho, T., Akira, S., Miyake, K., Tsutsui, H., Saito, T., Nishimura, I., Tsuji, N.M. (2013). Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-β. Immunity 38, 1187-1197.
  5. Masuda, K., Ripley, B., Nishimura, R., Mino, T., Takeuchi, O., Kiyonari, H., Shioi, G., Kishimoto, T. (2013). Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo. Proc. Natl. Acad. Sci. USA 110, 9409-9414.
  6. Uehata, T., Iwasaki, H., Vandenbon, Matsushita, K., Cuellar, E.H., Kuniyoshi, K., Satoh, T., Mino, T., Suzuki, Y., Standley, D.M., Tsujimura, T., Rakugi, H., Isaka, Y., Takeuchi, O., Akira, S. (2013). Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation. Cell 153, 1036-1049.
  7. Fukasaka, M., Ori, D., Kawagoe, T., Uematsu, S., Maruyama, K., Okazaki, T., Kozaki, T., Imamura, T., Tartey, S., Mino, T., Satoh, T., Akira, S., Takeuchi, O. (2013). Critical Role of AZI2 in GM-CSF-Induced Dendritic Cell Differentiation. J. Immunol. 190, 5702-5711.
  8. Satoh, T., Kidoya, H., Naito, H., Yamamoto, M., Takemura, N., Nakagawa, K., Yoshioka, Y., Morii, E., Takakura, N., Takeuchi, O., Akira, S. (2013). Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages. Nature 495, 524-528.
  9. Ori, D., Kato, H., Sanjo, H., Tartey, S., Mino, T., Akira, S., Takeuchi, O. (2013). Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs. J. Immunol. 190, 4037-4045. [The Journal of Immunology] [PubMed]
  10. Sandig, H., Jobbings, C.E., Roldan, N.G., Whittingham-Dowd, J., Orinska, Z., Takeuchi, O., Akira, S., Bulfone-Paus, S. (2013). IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation. Eur. J. Immunol. 43, 979-988.
  11. Mino, T., Mori, T., Aoyama, Y., Sera, T. (2013). Gene- and protein-delivered zinc finger-staphylococcal nuclease hybrid for inhibition of DNA replication of human papillomavirus. PLoS One 8, e56633.
  12. Mino, T., Takeuchi, O. (2013). Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation. Biotechnol. Genet. Eng. Rev. 29, 49-60. [Biotechnol. Genet. Eng. Rev.] [PubMed].

2012年

  1. Maruyama, K., Fukasaka, M., Vandenbon, A., Saitoh, T., Kawasaki, T., Kondo, T., Yokoyama, K.K., Kidoya, H., Takakura, N., Standley, D., Takeuchi, O., Akira, S. (2012). The Transcription Factor Jdp2 Controls Bone Homeostasis and Antibacterial Immunity by Regulating Osteoclast and Neutrophil Differentiation. Immunity 37, 1024-1036.
  2. Maruyama, K., Kawagoe, T., Kondo, T., Akira, S.*, Takeuchi, O.* (*correspondence). (2012). TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation. J. Biol. Chem. 287, 29114-29124.
  3. Abe, T., Fukuhara, T., Wen, X., Ninomiya, A., Moriishi, K., Maehara, Y., Takeuchi, O., Kawai, T., Akira, S., Matsuura, Y. (2012). CD44 Participates in IP-10 Induction in Cells in Which Hepatitis C Virus RNA Is Replicating, through an Interaction with Toll-Like Receptor 2 and Hyaluronan. J. Virol. 86, 6159-6170.
  4. Lee, K.G., Xu, S., Kang, Z.H., Huo, J., Huang, M., Liu, D., Takeuchi, O., Akira, S., Lam, K.P. (2012). Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response. Proc. Natl. Acad. Sci. USA 109, 5791-5796.
  5. Schuessler, A., Funk, A., Lazear, H.M., Cooper, D.A., Torres, S., Daffis, S., Jha, B.K., Kumagai, Y., Takeuchi, O., Hertzog, P., Silverman, R., Akira, S., Barton, D.J., Diamond, M.S., Khromykh, A.A. (2012). West Nile virus non-coding subgenomic RNA contributes to viral evasion of type I interferon-mediated antiviral response. J. Virol. 86, 5708-5718.
  6. Deshmukh, S.D., Muller, S., Hese, K., Rauch, K.S., Wennekamp, J., Takeuchi, O., Akira, S., Golenbock, D.T., Henneke, P. (2012). NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA. J. Immunol. 188, 774-780.
  7. Abe, Y., Fujii, K., Nagata, N., Takeuchi, O., Akira, S., Oshiumi, H., Matsumoto, M., Seya, T., Koike, S. (2012). The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice. J. Virol. 86, 185-194.
  8. Takeuchi, O. (2012). IRF3: a molecular switch in pathogen responses. Nat. Immunol. 13, 634-635. [Nat. Immunol.] [PubMed].

2011年

  1. Iwasaki, H., Takeuchi, O.*, Teraguchi, S., Matsushita, K., Uehata, T., Kuniyoshi, K., Satoh, T., Saitoh, T., Matsushita, M., Standley, D.M., Akira, S.* (*correspondence). (2011). The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. Nat. Immunol. 12, 1167-1175.
  2. Clark, K., Takeuchi, O., Akira, S., Cohen, P. (2011). The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling. Proc. Natl. Acad. Sci. USA 108, 17093-17098.
  3. Saitoh, T., Satoh, T., Yamamoto, N., Uematsu, S., Takeuchi, O., Kawai, T., Akira, S. (2011). Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells. Immunity 34, 352-363.
  4. Lee, P.Y., Kumagai, Y., Xu, Y., Li, Y., Barker, T., Liu, C., Sobel, E.S., Takeuchi, O., Akira, S., Satoh, M., Reeves, W.H. (2011). IL-1α modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oil. J. Immunol. 186, 1747-1754.
  5. Joung, S.M., Park, Z.Y., Rani, S., Takeuchi, O., Akira, S., Lee, J.Y. (2011). Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1. J. Immunol. 186, 499-507.
  6. Matsumoto, K., Kan-O, K., Eguchi-Tsuda, M., Fukuyama, S., Asai, Y., Matsumoto, T., Moriwaki, A., Matsunaga, Y., Tsutsui, H., Kawai, T., Takeuchi, O., Akira, S., Yagita, H., Azuma, M., Nakanishi, Y., Inoue, H. (2011). Essential Role of B7-H1 in Double-stranded RNA-induced Augmentation of an Asthma Phenotype in Mice. Am. J. Respir. Cell Mol. Biol. 45, 31-39.
  7. Takeuch, O., Akira, S. (2011). Epigenetic control of macrophage polarization. Eur. J. Immunol. 41, 2490-2493.

2010年

  1. Oshiumi, H., Ikeda, M., Matsumoto, M., Watanabe, A., Takeuchi, O., Akira, S., Kato, N., Shimotohno, K., Seya, T. (2010). Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction. PLoS One 5, e14258.
  2. Ren, D., Tu, H.C., Kim, H., Wang, G.X., Bean, G.R., Takeuchi, O., Jeffers, J.R., Zambetti, G.P., Hsieh, J.J., Cheng, E.H. (2010). BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science 330, 1390-1393.
  3. Miyake, T., Satoh, T., Kato, H., Matsushit, K., Kumagai, Y., Vandenbon, A., Tani, T., Muta, T., Akira, S., Takeuchi, O. (2010). IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18. Proc. Natl. Acad. Sci. USA 107, 17680-17685.
  4. Hashiguchi, S., Yamaguchi, Y., Takeuchi, O., Akira, S., Sugimura, K. (2010). Immunological basis of M13 phage vaccine: Regulation under MyD88 and TLR9 signaling. Biochem. Biophys. Res. Commun. 402, 19-22.
  5. *Satoh, T., *Takeuchi, O., Vandenbon, A., Yasuda, K., Tanaka, Y., Kumagai, Y., Miyake, T., Matsushita, K., Okazaki, T., Saitoh, T., Honma, K., Matsuyama, T., Yui, K., Tsujimura, T., Standley, D.M., Nakanishi, K., Nakai, K., Akira, S. (*Equal contribution). (2010). The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat. Immunol. 11, 936-944.
  6. Arimoto, K., Funami, K., Saeki, Y., Tanaka, K., Okawa, K., Takeuchi, O., Akira, S., Murakami, Y., Shimotohno, K. (2010). Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense. Proc. Natl. Acad. Sci. USA 107, 15856-15861.
  7. Schulz, O., Pichlmair, A., Rehwinkel, J., Rogers, N.C., Scheuner, D., Kato, H., Takeuchi, O., Akira, S., Kaufman, R.J., Reis e Sousa, C. (2010). Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. Cell Host Microbe. 7, 354-361.
  8. Ando, K., Hasegawa, K., Shindo, K., Furusawa, T., Fujino, T., Kikugawa, K., Nakano, H., Takeuchi, O., Akira, S., Akiyama, T., Gohda, J., Inoue, J., Hayakawa, M. (2010). Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling. FEBS J. 277, 2051-2066.
  9. Berger, M., Krebs, P., Crozat, K., Li, X., Croker, B.A., Siggs, O.M., Popkin, D., Du, X., Lawson, B.R, Theofilopoulos, A.N., Xia, Y., Khovananth, K.Y., Moresco, E.M., Satoh, T., Takeuchi, O., Akira, S., Beutler, B. (2010). An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nat. Immunol. 11, 335-343.
  10. Satoh, T., Kato, H., Kumagai, Y., Yoneyama, M., Sato, S., Matsushita, K., Tsujimura, T., Fujita, T., Akira, S., Takeuchi, O. (2010). LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc. Natl. Acad. Sci. USA 107, 1512-1517.
  11. Kirsch, D.G., Santiago, P.M., di Tomaso, E., Sullivan, J.M., Hou, W.S., Dayton, T., Jeffords, L.B., Sodha, P., Mercer, K.L., Cohen, R., Takeuchi, O., Korsmeyer, S.J., Bronson, R.T., Kim, C.F., Haigis, K.M., Jain, R.K., Jacks, T. (2010). p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science 327, 593-596.
  12. Tseng, P.-H., Matsuzawa, A., Zhang, W., Mino, T., Vignali, D.A.A., Karin, M. (2010). Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat. Immunol. 11, 70-75.
  13. Takeuchi, O., Akira, S. (2010). Pattern recognition receptors and inflammation. Cell 140, 805-820.

2009年

  1. Ishikawa, E., Ishikawa, T., Morita, Y.S., Toyonaga, K., Yamada, H., Takeuchi, O., Kinoshita, T., Akira, S., Yoshikai, Y., Yamasaki, S. (2009). Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J. Exp. Med. 206, 2879-2888.
  2. Saitoh, T., Fujita, N., Hayashi, T., Takahara, K., Satoh, T., Lee, H., Matsunaga, K., Kageyama, S., Omori, H., Noda, T., Yamamoto, N., Kawai, T., Ishii, K., Takeuchi, O., Yoshimori, T., Akira, S. (2009). Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc. Natl. Acad. Sci. USA 106, 20842-20846.
  3. Kim, H., Tu, H.C., Ren, D., Takeuchi, O., Jeffers, J.R., Zambetti, G.P., Hsieh, J.J., Cheng, E.H. (2009). Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Mol. Cell. 36, 487-499.
  4. Choi, M.K., Wang, Z., Ban, T., Yanai, H., Lu, Y., Koshiba, R., Nakaima, Y., Hangai, S., Savitsky, D., Nakasato, M., Negishi, H., Takeuch,i O., Honda, K., Akira, S., Tamura, T., Taniguchi, T. (2009). A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA. Proc. Natl. Acad. Sci. USA 106, 17870-17875.
  5. *Kawagoe, T., *Takeuchi, O., Takabatake, Y., Kato, H., Isaka, Y., Tsujimura, T., Akira, S. (*Equal contribution). (2009). TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nat. Immunol. 10, 965-972.
  6. Pichlmair, A., Schulz, O., Tan, C.P., Rehwinkel, J., Kato, H., Takeuchi, O., Akira, S., Way, M., Schiavo, G., Reis e Sousa. C. (2009). Activation of MDA5 requires higher-order RNA structures generated during virus infection. J. Virol. 83, 10761-10769.
  7. Miyake, T., Kumagai, Y., Kato, H., Guo, Z., Matsushita, K., Satoh, T., Kawagoe, T., Kumar, H., Jang, M.H., Kawai, T., Tani, T., Takeuchi, O., Akira, S. (2009). Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways. J. Immunol. 183, 2522-2528.
  8. Schlee, M., Roth, A., Hornung, V., Hagmann, C.A., Wimmenauer, V., Barchet, W., Coch, C., Janke, M., Mihailovic, A., Wardle, G., Juranek, S., Kato, H., Kawai, T., Poeck, H., Fitzgerald, K.A., Takeuchi, O., Akira, S., Tuschl, T., Latz, E., Ludwig, J., Hartmann, G. (2009). Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity 31, 25-34.
  9. Konno, H., Yamamoto, T., Yamazaki, K., Gohda, J., Akiyama, T., Semba, K., Goto, H., Kato, A., Yujiri, T., Imai, T., Kawaguchi, Y., Su, B., Takeuchi, O., Akira, S., Tsunetsugu-Yokota, Y., Inoue, J. (2009). TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA. PLoS One 4, e5674.
  10. Abe, T., Kaname, Y., Wen, X., Tani, H., Moriishi, K., Uematsu, S., Takeuchi, O., Ishii, K.J., Kawai, T., Akira, S., Matsuura, Y. (2009). Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner. J. Virol. 83, 7629-7640.
  11. *Matsushita, K., *Takeuchi, O., Standley, D.M., Kumagai, Y., Kawagoe, T., Miyake, T., Satoh, T., Kato, H., Tsujimura, T., Nakamura, H., Akira, S. (*Equal contribution). (2009). Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature 458, 1185-1190.
  12. Kumagai, Y., Kumar, H., Koyama, S., Kawai, T., Takeuchi, O., Akira, S. (2009). Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells. J. Immunol. 182, 3960-3964.
  13. Yamasaki, S., Matsumoto, M., Takeuchi, O., Matsuzawa, T., Ishikawa, E., Sakuma, M., Tateno, H., Uno, J., Hirabayashi, J., Mikami, Y., Takeda, K., Akira, S., Saito, T. (2009). C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc. Natl. Acad. Sci. USA 106, 1897-1902.
  14. Kurokawa, K., Lee, H., Roh, K.B., Asanuma, M., Kim, Y.S., Nakayama, H., Shiratsuchi, A., Choi, Y., Takeuchi, O., Kang, H.J., Dohmae, N., Nakanishi, Y., Akira, S., Sekimizu, K., Lee, B.L. (2009). The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2. J. Biol. Chem. 284, 8406-8411.
  15. Steimer, D.A., Boyd, K., Takeuchi, O., Fisher, J.K., Zambetti, G.P., Opferman, J.T. (2009). Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood 113, 2805-2815.
  16. Mino, T., Aoyama, Y., Sera, T. (2009). Efficient double-stranded DNA cleavage by artificial zinc-finger nucleases composed of one zinc-finger protein and a single-chain FokI dimer. J. Biotechnol. 140, 156-161.
  17. Takeuchi, O., Akira, S. (2009). Innate immunity to virus infection. Immunol. Rev. 227, 75-86.

2008年以前

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Takeuchi Lab.竹内研究室

〒606-8501
京都市左京区吉田近衛町
京都大学大学院医学研究科
医学専攻分子生体統御学講座
医化学分野
医学部A棟207号室
E-mail:otake @ mfour.med.kyoto-u.ac.jp
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TEL: 075-753-9500
FAX: 075-753-9502

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