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2008年以前の原著論文

  1. Mandal, M., Crusio, K.M., Meng, F., Liu, S., Kinsella, M., Clark, M.R., Takeuchi, O., Aifantis, I. (2008). Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid. Proc. Natl. Acad. Sci. USA 105, 20840-20845.
  2. Lee, P.Y., Kumagai, Y., Li, Y., Takeuchi, O., Yoshida, H., Weinstein, J., Kellner, E.S., Nacionales, D., Barker, T., Kelly-Scumpia, K., van Rooijen, N., Kumar, H., Kawai, T., Satoh, M., Akira, S., Reeves, W.H. (2008). TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupus. J. Exp. Med. 205, 2995-3006.
  3. Saitoh, T., Fujita, N., Jang, M.H., Uematsu, S., Yang, B.G., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., Tanaka, K., Kawai, T., Tsujimura, T., Takeuchi, O., Yoshimori, T., Akira, S. (2008). Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456, 264-268.
  4. Kato, H., Takeuchi, O., Mikamo-Satoh, E., Hirai, R., Kawai, T., Matsushita, K., Hiiragi, A., Dermody, T.S., Fujita, T., Akira, S. (2008). Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J. Exp. Med. 205, 1601-1610.
  5. Kawagoe, T., Sato, S., Matsushita, K., Kato, H., Matsui, K., Kumagai, Y., Saitoh, T., Kawai, T., Takeuchi, O., Akira, S. (2008). Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. Nat. Immuno. 9, 684-691.
  6. Ishii, K.J., Kawagoe, T., Koyama, S., Matsui, K., Kumar, H., Kawai, T., Uematsu, S., Takeuchi, O., Takeshita, F., Coban, C., Akira, S. (2008). TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 451, 725-729.
  7. Bhattacharjee, R.N., Park, K.S., Chen, X., Iida, T., Honda, T., Takeuchi, O., Akira, S. (2008). Translocation of VP1686 upregulates RhoB and accelerates phagocytic activity of macrophage through actin remodeling. J. Microbiol. Biotechnol. 18, 171-175.
  8. Goto, A., Matsushita, K., Gesellchen, V., Chamy, L.E., Kuttenkeuler, D., Takeuchi, O., Hoffmann, J.A., Akira, S., Boutros, M., Reichhart, J.M. (2008). Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat. Immunol. 9, 97-104.
  9. Jung, A., Kato, H., Kumagai, Y., Kumar, H., Kawai, T., Takeuchi, O., Akira, S. (2008). Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces cytotoxic T cell response via MyD88. J. Virol. 82, 196-206.
  10. Mino, T., Mori, T., Aoyama, Y., Sera, T. (2008). Cell-permeable artificial zinc-finger proteins as potent antiviral drugs for human papillomaviruses. Arch. Virol. 153, 1291-1298.
  11. Beutler, B., Eidenschenk, C., Crozat, K., Imler, J.L., Takeuchi, O., Hoffmann, J.A., Akira, S. (2007). Genetic analysis of resistance to viral infection. Nat. Rev. Immunol. 7, 753-766.
  12. Yamamoto, M., Uematsu, S., Okamoto, T., Matsuura, Y., Sato, S., Kumar, H., Satoh, T., Saitoh, T., Takeda, K., Ishii, K.J., Takeuchi, O., Kawai, T., Akira, S. (2007). Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. J. Exp. Med. 204, 2233-2239.
  13. Kumagai, Y., Takeuchi, O., Kato, H., Kumar, H., Matsui, K., Morii, E., Aozasa, K., Kawai, T., Akira, S. (2007). Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. Immunity 27, 240-252.
  14. Kirsch, D.G., Dinulescu, D.M., Miller, J.B., Grimm, J., Santiago, P.M., Young, N.P., Nielsen, G.P., Quade, B.J., Chaber, C.J., Schultz, C.P., Takeuchi, O., Bronson, R.T., Crowley, D., Korsmeyer, S.J., Yoon, S.S., Hornicek, F.J., Weissleder, R., Jacks, T. (2007). A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat. Med. 13, 992-997.
  15. Abe, T., Kaname, Y., Hamamoto, I., Tsuda, Y., Wen, X., Taguwa, S., Moriishi, K., Takeuchi, O., Kawai, T., Kanto, T., Hayashi, N., Akira, S., Matsuura, Y. (2007). Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines. J. Virol. 81, 8953-8966.
  16. Kawagoe, T., Sato, S., Jung, A., Yamamoto, M., Matsui, K., Kato, H., Uematsu, S., Takeuchi, O., Akira, S. (2007). Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. J. Exp. Med. 204, 1013-1024.
  17. Gack, M.U., Shin, Y.C., Joo, C.H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z., Inoue, S., Jung, J.U. (2007). TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446, 916-920.
  18. Coban, C., Ishii, K.J., Uematsu, S., Arisue, N., Sato, S., Yamamoto, M., Kawai, T., Takeuchi, O., Hisaeda, H., Horii, T., Akira, S. (2006). Pathological role of Toll-like receptor signaling in cerebral malaria. Int. Immunol. 19, 67-79.
  19. Yamamoto, M., Sato, S., Saitoh, T., Sakurai, H., Uematsu, S., Kawai, T., Ishii, K.J., Takeuchi, O., Akira, S. (2006). Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling. J. Immunol. 177, 7520-7524.
  20. Matsui, K., Kumagai, Y., Kato, H., Sato, S., Kawagoe, T., Uematsu, S., Takeuchi, O., Akira, S. (2006). Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells. J. Immunol. 177, 5785-5789.
  21. Bhattacharjee, R.N., Park, K.S., Kumagai, Y., Okada, K., Yamamoto, M., Uematsu, S., Matsui, K., Kumar, H., Kawai, T., Iida, T., Honda, T., Takeuchi, O., Akira, S. (2006). VP1686, a Vibrio type III secretion protein, induces toll-like receptor independent apoptosis in macrophage through NF-kappa B inhibition. J. Biol. Chem. 281, 36897-36904.
  22. Sato, S., Sanjo, H., Tsujimura, T., Ninomiya-Tsuji, J., Yamamoto, M., Kawai, T., Takeuchi, O., Akira, S. (2006). TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int. Immunol. 18, 1405-1411.
  23. Yamamoto, M., Okamoto, T., Takeda, K., Sato, S., Sanjo, H., Uematsu, S., Saitoh, T., Yamamoto, N., Sakurai, H., Ishii, K.J., Yamaoka, S., Kawai, T., Matsuura, Y., Takeuchi, O., Akira, S. (2006). Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat. Immunol. 7, 962-970.
  24. Uematsu, S.*, Jang, M.H.*, Chevrier, N., Guo, Z., Kumagai, Y., Yamamoto, M., Kato, H., Sougawa, N., Matsui, H., Kuwata, H., Hemmi, H., Coban, C., Kawai, T., Ishii, K.J., Takeuchi, O., Miyasaka, M., Takeda, K., Akira, S. (*equal contribution). (2006). Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c(+) lamina propria cells. Nat. Immunol. 7, 868-874.
  25. Kumar, H.*, Kawai, T.*, Kato, H., Sato, S., Takahashi, K., Coban, C., Yamamoto, M., Uematsu, S., Ishii, K.J., Takeuchi, O., Akira, S. (*equal contribution). (2006). Essential role of IPS-1 in innate immune responses against RNA viruses. J. Exp. Med. 203, 1795-1803.
  26. Kato, H.*, Takeuchi, O.*, Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K.J., Yamaguchi, O., Otsu, K., Tsujimura, T., Koh, C.S., Reis E Sousa, C., Matsuura, Y., Fujita, T., Akira, S. (*equal contribution). (2006). Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441, 101-105.
  27. Lapaque, N., Takeuchi, O., Corrales, F., Akira, S., Moriyon, I., Howard, J.C., Gorvel, J.P. (2006). Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides. Cell Microbiol. 8, 401-413.
  28. Mino, T., Hatono, T., Matsumoto, N., Mori, T., Mineta, Y., Aoyama, Y., Sera, T. (2006). Inhibition of DNA Replication of Human Papillomavirus by Artificial Zinc Finger Proteins. J. Virol. 80, 5405-5412.
  29. Bhattacharjee, R.N., Park, K.S., Uematsu, S., Okada, K., Hoshino, K., Takeda, K., Takeuchi, O., Akira, S., Iida, T., Honda, T. (2005). Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest. FEBS Lett. 579, 6604-6610.
  30. Kimura, A., Naka, T., Muta, T., Takeuchi, O., Akira, S., Kawase, I., Kishimoto, T. (2005). Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT. Proc. Natl. Acad. Sci. USA 102, 17089-1794.
  31. Ishii, K.J., Coban, C., Kato, H., Takahashi, K., Torii, Y., Takeshita, F., Ludwig, H., Sutter, G., Suzuki, K., Hemmi, H., Sato, S., Yamamoto, M., Uematsu, S., Kawai, T., Takeuchi, O., Akira, S. (2006). A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat. Immunol. 7, 40-48.
  32. Sato, S.*, Sanjo, H.*, Takeda, K., Ninomiya-Tsuji, J., Yamamoto, M., Kawai, T., Matsumoto, K., Takeuchi, O., Akira, S. (*equal contribution). (2005). Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat. Immunol. 6, 1087-195.
  33. Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K.J., Takeuchi, O., Akira, S. (2005). IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 6, 981-988.
  34. Balloy, V., Si-Tahar, M., Takeuchi, O., Philippe, B., Nahori, M.A., Tanguy, M., Huerre, M., Akira, S., Latge, J.P., Chignard, M. (2005). Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis. Infect. Immun. 73, 5420-5425.
  35. Schinzel, A.C., Takeuchi, O., Huang, Z., Fisher, J.K., Zhou, Z., Rubens, J., Hetz, C., Danial, N.N., Moskowitz, M.A., Korsmeyer, S.J. (2005). Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc. Natl. Acad. Sci. USA 102, 12005-12010.
  36. Takeuchi, O., Fisher, J., Suh, H., Harada, H., Malynn, B.A., Korsmeyer, S.J. (2005). Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc. Natl. Acad. Sci. USA 102, 11272-11277.
  37. Bhattacharjee, R.N., Park, K.S., Okada, K., Kumagai, Y., Uematsu, S., Takeuchi, O., Akira, S., Iida, T., Honda, T. (2005). Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus. Biochem. Biophys. Res. Commun. 335, 328-334.
  38. Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., Tsujimura, T., Takeda, K., Fujita, T., Takeuchi, O., Akira, S. (2005). Cell Type-Specific Involvement of RIG-I in Antiviral Response. Immunity 23, 19-28.
  39. Henneke, P., Morath, S., Uematsu, S., Weichert, S., Pfitzenmaier, M., Takeuchi, O., Muller, A., Poyart, C., Akira, S., Berner, R., Teti, G., Geyer, A., Hartung, T., Trieu-Cuot, P., Kasper, D.L., Golenbock, D.T. (2005). Role of lipoteichoic Acid in the phagocyte response to group B streptococcus. J. Immunol. 174, 6449-6455.
  40. Uematsu, S., Sato, S., Yamamoto, M., Hirotani, T., Kato, H., Takeshita, F., Matsuda, M., Coban, C., Ishii, K.J., Kawai, T., Takeuchi, O., Akira, S. (2005). Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J. Exp. Med. 201, 915-923.
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  42. Coban, C., Ishii, K.J., Kawai, T., Hemmi, H., Sato, S., Uematsu, S., Yamamoto, M., Takeuchi, O., Itagaki, S., Kumar, N., Horii, T., Akira, S. (2005). Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J. Exp. Med. 201, 19-25.
  43. Knuefermann, P., Sakata, Y., Baker, J.S., Huang, C.H., Sekiguchi, K., Hardarson, H.S., Takeuchi, O., Akira, S., Vallejo, J.G. (2004). Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart. Circulation 110, 3693-3698.
  44. Kawai, T., Sato, S., Ishii, K.J., Coban, C., Hemmi, H., Yamamoto, M., Terai, K., Matsuda, M., Inoue, J.I., Uematsu, S., Takeuchi, O., Akira, S. (2004). Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5, 1061-1068.
  45. Yamamoto, M., Yamazaki, S., Uematsu, S., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Kuwata, H., Takeuchi, O., Takeshige, K., Saitoh, T., Yamaoka, S., Yamamoto, N., Yamamoto, S., Muta, T., Takeda, K., Akira, S. (2004). Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature 430, 218-222.
  46. Hemmi, H., Takeuchi, O., Sato, S., Yamamoto, M., Kaisho, T., Sanjo, H., Kawai, T., Hoshino, K., Takeda, K., Akira, S. (2004). The Roles of Two IkappaB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection. J. Exp. Med. 199, 1641-1650.
  47. Okamoto, M., Oh-E, G., Oshikawa, T., Furuichi, S., Tano, T., Ahmed, S.U., Akashi, S., Miyake, K., Takeuchi, O., Akira, S., Himeno, K., Sato, M., Ohkubo, S. (2004). Toll-Like Receptor 4 Mediates the Antitumor Host Response Induced by a 55-Kilodalton Protein Isolated from Aeginetia indica L., a Parasitic Plant. Clin. Diagn. Lab. Immunol. 11, 483-95.
  48. Gomes, M.S., Florido, M., Cordeiro, J.V., Teixeira, C.M., Takeuchi, O., Akira, S., Appelberg, R. (2004). Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium. Immunology 111, 179-185.
  49. Honstettre, A., Ghigo, E., Moynault, A., Capo, C., Toman, R., Akira, S., Takeuchi, O., Lepidi, H., Raoult, D., Mege, J.L. (2004). Lipopolysaccharide from Coxiella burnetii is involved in bacterial phagocytosis, filamentous actin reorganization, and inflammatory responses through Toll-like receptor 4. J. Immunol. 172, 3695-3703.
  50. Knapp, S., Wieland, C.W., van 't Veer, C., Takeuchi, O., Akira, S., Florquin, S., van der Poll, T. (2004). Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense. J. Immunol. 172, 3132-3138.
  51. Shiratsuchi, A., Watanabe, I., Takeuchi, O., Akira, S., Nakanishi, Y. (2004). Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages. J. Immunol. 172, 2039-2047.
  52. Shishido, T., Nozaki, N., Yamaguchi, S., Shibata, Y., Nitobe, J., Miyamoto, T., Takahashi, H., Arimoto, T., Maeda, K., Yamakawa, M., Takeuchi, O., Akira, S., Takeishi, Y., Kubota, I. (2003). Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation 108, 2905-2910.
  53. Misra, A., Takeuchi, O., Akira, S., Mann, D., Vallejo, J. (2003). Functional significance of toll-like receptor-2 mediated signaling in the heart following acute ischemia/infarction. J. Am. Coll. Cardiol. 41, 372.
  54. Iiyama, R., Kanai, T., Uraushihara, K., Ishikura, T., Makita, S., Totsuka, T., Yamazaki, M., Nakamura, T., Miyata, T., Yoshida, H., Takeuchi, O., Hoshino, K., Takeda, K., Ishikawa, H., Akira, S., Watanabe, M. (2003). Normal Development of the Gut-Associated Lymphoid Tissue Except Peyer's Patch in MyD88-Deficient Mice. Scand. J. Immunol. 58, 620-627.
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  59. Tamai, R., Sugawara, S., Takeuchi, O., Akira, S., Takada, H. (2003). Synergistic effects of lipopolysaccharide and interferon-gamma in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, Toll-like receptor 4, MD-2 and MyD88 expression. J. Endotoxin. Res. 9, 145-153.
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  61. Jouault, T., Ibata-Ombetta, S., Takeuchi, O., Trinel, P.A., Sacchetti, P., Lefebvre, P., Akira, S., Poulain, D. (2003). Candida albicans Phospholipomannan Is Sensed through Toll-Like Receptors. J. Infect. Dis. 188, 165-172.
  62. Yazawa, N., Fujimoto, M., Sato, S., Miyake, K., Asano, N., Nagai, Y., Takeuchi, O., Takeda, K., Okochi, H., Akira, S., Tedder, T.F., Tamaki, K. (2003). CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. Blood 102, 1374-1380.
  63. Aosai, F., Chen, M., Kang, H.K., Mun, H.S., Norose, K., Piao, L.X., Kobayashi, M., Takeuchi, O., Akira, S., Yano, A. (2002). Toxoplasma gondii-derived heat shock protein HSP70 functions as a B cell mitogen. Cell Stress Chaperones 7, 357-364.
  64. Okamoto, M., Oshikawa, T., Tano, T., Ohe, G., Furuichi, S., Nishikawa, H., Ahmed, S.U., Akashi, S., Miyake, K., Takeuchi, O., Akira, S., Moriya, Y., Matsubara, S., Ryoma, Y., Saito, M., Sato, M. (2003). Involvement of Toll-Like Receptor 4 Signaling in Interferon-gamma Production and Antitumor Effect by Streptococcal Agent OK-432. J. Natl. Cancer Inst. 95, 316-326.
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  73. Henneke, P., Takeuchi, O., Malley, R., Lien, E., Ingalls, R.R., Freeman, M.W., Mayadas, T., Nizet, V., Akira, S., Kasper, D.L., Golenbock, D.T. (2002). Cellular Activation, Phagocytosis, and Bactericidal Activity Against Group B Streptococcus Involve Parallel Myeloid Differentiation Factor 88-Dependent and Independent Signaling Pathways. J. Immunol. 169, 3970-3977.
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  75. Yamao, T., Noguchi, T., Takeuchi, O., Nishiyama, U., Morita, H., Hagiwara, T., Akahori, H., Kato, T., Inagaki, K., Okazawa, H., Hayashi, Y., Matozaki, T., Takeda, K., Akira, S., Kasuga, M. (2002). Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1. J. Biol. Chem. 277, 39833-39839.
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  77. Kim, J., Ochoa, M.T., Krutzik, S.R., Takeuchi, O., Uematsu, S., Legaspi, A.J., Brightbill, H.D., Holland, D., Cunliffe, W.J., Akira, S., Sieling, P.A., Godowski, P.J., Modlin, R.L. (2002). Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses. J. Immunol. 169, 1535-1541.
  78. Sato, S., Takeuchi, O., Fujita, T., Tomizawa, H., Takeda, K., Akira, S. (2002). A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways. Int. Immunol. 14, 783-791.
  79. Kaisho, T., Hoshino, K., Iwabe, T., Takeuchi, O., Yasui, T., Akira, S. (2002). Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation. Int. Immunol. 14, 695-700.
  80. Flo, T.H., Ryan, L., Latz, E., Takeuchi, O., Monks, B.G., Lien, E., Halaas, O., Akira, S., Skjak-Braek, G., Golenbock, D.T., Espevik, T. (2002). Involvement of toll-like receptor(TLR)2 and TLR4 in cell activation by mannuronic acid polymers. J. Biol. Chem. 277, 35489-35495.
  81. Takeuchi, O., Sato, S., Horiuchi, T., Hoshino, K., Takeda, K., Dong, Z., Modlin, R.L., Akira, S. (2002). Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins. J. Immunol. 169, 10-14.
  82. Coelho, P.S., Klein, A., Talvani, A., Coutinho, S.F., Takeuchi, O., Akira, S., Silva, J.S., Canizzaro, H., Gazzinelli, R.T., Teixeira, M.M. (2002). Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages. J. Leukoc. Biol. 71, 837-844.
  83. Tamai, R., Sakuta, T., Matsushita, K., Torii, M., Takeuchi, O., Akira, S., Akashi, S., Espevik, T., Sugawara, S., Takada, H. (2002). Human Gingival CD14(+) Fibroblasts Primed with Gamma Interferon Increase Production of Interleukin-8 in Response to Lipopolysaccharide through Up-Regulation of Membrane CD14 and MyD88 mRNA Expression. Infect. Immun. 70, 1272-1278.
  84. Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., Akira, S. (2002). Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3, 196-200.
  85. Henneke, P., Takeuchi, O., van Strijp, J.A., Guttormsen, H.K., Smith, J.A., Schromm, A.B., Espevik, T.A., Akira, S., Nizet, V., Kasper, D.L., Golenbock, D.T. (2001). Novel Engagement of CD14 and Multiple Toll-Like Receptors by Group B Streptococci. J. Immunol. 167, 7069-7076.
  86. Adachi, K., Tsutsui, H., Kashiwamura, S.I., Seki, E., Nakano, H., Takeuchi, O., Takeda, K., Okumura, K., Van Kaer, L., Okamura, H., Akira, S., Nakanishi, K. (2001). Plasmodium berghei Infection in Mice Induces Liver Injury by an IL-12- and Toll-Like Receptor/Myeloid Differentiation Factor 88-Dependent Mechanism. J. Immunol. 167, 5928-5934.
  87. Kawai, T., Takeuchi, O., Fujita, T., Inoue Ji, J., Muhlradt, P.F., Sato, S., Hoshino, K., Akira, S. (2001). Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes. J. Immunol. 167, 5887-5894.
  88. Sugawara, S., Yang, S., Iki, K., Hatakeyama, J., Tamai, R., Takeuchi, O., Akashi, S., Espevik, T., Akira, S., Takada, H. (2001). Monocytic Cell Activation by Nonendotoxic Glycoprotein from Prevotella intermedia ATCC 25611 Is Mediated by Toll-Like Receptor 2. Infect. Immun. 69, 4951-4957.
  89. Takeuchi, O., Kawai, T., Muhlradt, P.F., Morr, M., Radolf, J.D., Zychlinsky, A., Takeda, K., Akira, S. (2001). Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int. Immunol. 13, 933-940.
  90. Campos, M.A., Almeida, I.C., Takeuchi, O., Akira, S., Valente, E.P., Procopio, D.O., Travassos, L.R., Smith, J.A., Golenbock, D.T., Gazzinelli, R.T. (2001). Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite. J. Immunol. 167, 416-423.
  91. Kaisho, T., Takeuchi, O., Kawai, T., Hoshino, K., Akira, S. (2001). Endotoxin-Induced Maturation of MyD88-Deficient Dendritic Cells. J. Immunol. 166, 5688-5694.
  92. Yang, S., Tamai, R., Akashi, S., Takeuchi, O., Akira, S., Sugawara, S., Takada, H. (2001). Synergistic Effect of Muramyldipeptide with Lipopolysaccharide or Lipoteichoic Acid To Induce Inflammatory Cytokines in Human Monocytic Cells in Culture. Infect. Immun. 69, 2045-2053.
  93. Thoma-Uszynski, S., Stenger, S., Takeuchi, O., Ochoa, M.T., Engele, M., Sieling, P.A., Barnes, P.F., Rollinghoff, M., Bolcskei, P.L., Wagner, M., Akira, S., Norgard, M.V., Belisle, J.T., Godowski, P.J., Bloom, B.R., Modlin, R.L. (2001). Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors. Science 291, 1544-1547.
  94. Filipp, D., Alizadeh-Khiavi, K., Richardson, C., Palma, A., Paredes, N., Takeuchi, O., Akira, S., Julius, M. (2001). Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation. Proc. Natl. Acad. Sci. USA 98, 603-608.
  95. Seki, E., Tsutsui, H., Nakano, H., Tsuji, N.M., Hoshino, K., Adachi, O., Adachi, K., Futatsugi, S., Kuida, K., Takeuchi, O., Okamura, H., Fujimoto, J., Akira, S., Nakanishi, K. (2001). Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1beta. J. Immunol. 166, 2651-2657.
  96. Nishiguchi, M., Matsumoto, M., Takao, T., Hoshino, M., Shimonishi, Y., Tsuji, S., Begum, N.A., Takeuchi, O., Akira, S., Toyoshima, K., Seya, T. (2001). Mycoplasma fermentans Lipoprotein M161Ag-Induced Cell Activation Is Mediated by Toll-Like Receptor 2: Role of N-Terminal Hydrophobic Portion in its Multiple Functions. J. Immunol. 166, 2610-2616.
  97. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., Akira, S. (2001). A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745.
  98. Perera, P.Y., Mayadas, T.N., Takeuchi, O., Akira, S., Zaks-Zilberman, M., Goyert, S.M., Vogel, S.N. (2001). CD11b/CD18 acts in concert with CD14 and toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J. Immunol. 166, 574-581.
  99. Sato, S., Nomura, F., Kawai, T., Takeuchi, O., Muhlradt, P.F., Takeda, K., Akira, S. (2000). Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J. Immunol.165, 7096-7101.
  100. Tsuji, S., Matsumoto, M., Takeuchi, O., Akira, S., Azuma, I., Hayashi, A., Toyoshima, K., Seya, T. (2000). Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guerin: involvement of toll-like receptors. Infect. Immun. 68, 6883-6890.
  101. Takeuchi, O., Hoshino, K., Akira, S. (2000). Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 165, 5392-5396.
  102. Hacker, H., Vabulas, R.M., Takeuchi, O., Hoshino, K., Akira, S., Wagner, H. (2000). Immune Cell Activation by Bacterial CpG-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor-Associated Factor (TRAF) 6. J. Exp. Med. 192, 595-600.
  103. Sakao, Y., Kawai, T., Takeuchi, O., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Takeda, K., Akira, S. (2000). Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting. Genomics 67, 1-7.
  104. Mokuno, Y., Matsuguchi, T., Takano, M., Nishimura, H., Washizu, J., Ogawa, T., Takeuchi, O., Akira, S., Nimura, Y., Yoshikai, Y. (2000). Expression of Toll-Like Receptor 2 on gammadelta T Cells Bearing Invariant Vgamma6/Vdelta1 Induced by Escherichia coli Infection in Mice. J. Immunol. 165, 931-940.
  105. Hashimoto, M., Imamura, Y., Morichika, T., Arimoto, K., Takeuchi, O., Takeda, K., Akira, S., Aoyama, K., Tamura, T., Kotani, S., Suda, Y., Kusumoto, S. (2000). Cytokine-inducing macromolecular glycolipids from enterococcus hirae: improved method for separation and analysis of its effects on cellular activation. Biochem. Biophys. Res. Commun. 273, 164-169.
  106. Takeuchi, O., Kaufmann, A., Grote, K., Kawai, T., Hoshino, K., Morr, M., Muhlradt, P.F., Akira, S. (2000). Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway. J. Immunol. 164, 554-557.
  107. Takeuchi, O., Takeda, K., Hoshino, K., Adachi, O., Ogawa, T., Akira, S. (2000). Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int. Immunol. 12, 113-117.
  108. Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., Akira, S. (1999). Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11, 443-451.
  109. Takeuchi, O., Kawai, T., Sanjo, H., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Takeda, K., Akira, S. (1999). TLR6: A novel member of an expanding toll-like receptor family. Gene 231, 59-65.
  110. Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., Akira, S. (1999). Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162, 3749-3752.
  111. Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., Akira, S. (1999). Limb and skin abnormalities in mice lacking IKKalpha. Science 284, 313-316.
  112. Haruna, M., Hayashi, K., Yano, H., Takeuchi, O., Sobue, K. (1993). Common structural and expressional properties of vertebrate caldesmon genes. Biochem. Biophys. Res. Commun. 197, 145-153.

2008年以前の総説

  1. Takeuchi, O., Akira, S. (2008). RIG-I-like antiviral protein in flies. Nat. Immunol. 9, 1327-1328.
  2. Kumagai, Y., Takeuchi, O., Akira, S. (2008). Pathogen recognition by innate receptors. J. Infect. Chemother. 14, 86-92.
  3. Takeuchi, O., Akira, S. (2008). MDA5/RIG-I and virus recognition. Curr. Opin. Immunol. 20, 17-22.
  4. Kumagai, Y., Takeuchi, O., Akira, S. (2008). TLR9 as a key receptor for the recognition of DNA. Adv. Drug Deliv. Rev. 60, 795-804.
  5. Takeuchi, O., Akira, S. (2007). Signaling pathways activated by microorganisms. Curr. Opin. Cell Biol. 19, 185-191.
  6. Akira, S., Uematsu, S., Takeuchi, O. (2006). Pathogen recognition and innate immunity. Cell 124, 783-801.
  7. Takeuchi, O., Hemmi, H., Akira, S. (2004). Interferon response induced by Toll-like receptor signaling. J. Endotoxin Res. 10, 252-256.
  8. Takeda, K., Takeuchi, O., Akira, S. (2002). Recognition of lipopeptides by Toll-like receptors. J. Endotoxin Res. 8, 459-463.
  9. Takeuchi, O., Akira, S. (2002). MyD88 as a bottle neck in Toll/IL-1 signaling. Curr. Top Microbiol. Immunol. 270, 155-167.
  10. Takeuchi, O., Akira, S. (2002). Genetic approaches to the study of Toll-like receptor function. Microbes Infect. 4, 887-895.
  11. Takeuchi, O., Akira, S. (2001). Toll-like receptors; their physiological role and signal transduction system. Int. Immunopharmacol. 1, 625-635.

Takeuchi Lab.竹内研究室

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京都市左京区吉田近衛町
京都大学大学院医学研究科
医学専攻分子生体統御学講座
医化学分野
医学部A棟207号室
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